SERUM MALONDIALDEHYDE AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES NON HYPERTENSIVE AND HYPERTENSIVE NON-DIABETES PATIENTS IN KOGI STATE, NIGERIA.
Keywords:
Hypertension, T2DM, Oxidative-stress and Inflammatory reaction.Abstract
Background: This study investigated the association of essential hypertension and type 2-diabetes mellitus (T2DM) with blood oxidative stress–related parameters in T2DM and hypertensive subjects attending Federal Medical Centre Lokoja, Kogi state. It aimed at determining gender susceptibility to oxidative-stress in T2DM and hypertension.
Method: A cross-sectional design of 50 subjects with T2DM, Hypertension and apparently healthy subjects (25-males and 25-females). Ages 40-50 years of subject with T2DM and Hypertension, Body mass index (BMI) of obese/overweight were selection criteria while smoking and alcoholism were exclusion criteria. Fasting sample was collected for assay of serum malondialdehyde (SMDA), C-reactive protein (CRP), total cholesterol (TC) and fasting blood sugar (FBS) using appropriate sample bottles.
Results: SMDA-4.02±0.13uMol/L, CRP-3.22±0.14mg/L, TC-6.28±0.74mMol/L of male-hypertensive subject and male-T2DM SMDA-3.35±0.48uMol/L, CRP-4.71±0.58mg/L, TC-5.39±0.88mMol/L, FBS-6.01±0.85mMol/L was statistically significant when compared with male apparently healthy subject SMDA-2.13±0.28uMol/L, CRP-1.58±0.43mg/L, TC-4.36±0.56mMol/L, FBS-4.45±0.32mMol/L. Meanwhile SMDA-4.59±0.38uMol/L, CRP-3.52±0.17mg/L, FBS-5.09±0.15mMol/L of female-hypertensive and SMDA-3.20±0.23uMol/L, FBS-6.35±1.11mMol/L of female-T2DM had p-value≤ 0.05 when compared with female apparently healthy subject SMDA-1.95±0.13uMol/L, CRP-1.28±0.51mg/L, FBS-4.33±0.36mMol/L. SMDA, TC and FBS had pvalue≤ 0.05 and CRP (p>0.05) when male and female-hypertensive subject were compared. SMDA, CRP and TC had pvalue≤ 0.05 and FBS has (p>0.05) when male and female-T2DM were compared.
Conclusion: This study revealed greater oxidative stress and inflammatory reaction in subject with hypertension and T2DM in both sex, female appears to be more prone to oxidative stress than male. Further study of these markers on the progression of these non-communicable diseases is recommended.
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